Cassano Spinola is a comune (municipality) in the Province of Alessandria in the Italian region Piedmont, located about 100 kilometres (62 mi) southeast of Turin and about 25 kilometres (16 mi) southeast of Alessandria.

Cassano Spinola borders the following municipalities: Carezzano, Novi Ligure, Pozzolo Formigaro, Sant'Agata Fossili, Sardigliano, Serravalle Scrivia, Stazzano, and Villalvernia.

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