The Central West End is a neighborhood in St. Louis, Missouri, stretching from Midtown's western edge to Union Boulevard and bordering on Forest Park with its array of free cultural institutions.

[2] Playwright Tennessee Williams grew up in the neighborhood, and the house of the renowned poet T. S. Eliot is located in the Central West End.

It is often mistaken as the location of Sally Benson's home, 5135 Kensington Avenue, which is the setting of her stories which were adapted into the movie Meet Me in St. Louis.

The Central West End's main commercial district runs along Euclid Avenue and stretches from Forest Park Parkway on the south to Delmar Boulevard on the north.

Modern residential buildings in Central West End include Park East Tower and One Hundred.