Eisenstein's work covers a wide range of topics, including the history of human civilization, economics, spirituality, and the ecology movement.

Noting the influence of conspiracy theories on Eisenstein's writing and activism, especially since the COVID-19 pandemic, Matthew Remski described him as the "poet philosopher of conspirituality.

[6] Eisenstein has published op-ed pieces in The Guardian and The Huffington Post on topics including genetic modification, the patenting of seeds[7][8] and debt.

[14] On May 15, 2023, Eisenstein announced that he had taken an advisor's position in the campaign of then-Democratic (later independent) Presidential candidate Robert F. Kennedy Jr.[15] In that capacity, he participated in a fundraising event, held June 27, 2023, bringing together several prominent anti-vaccine activists, such as Mikki Willis, Sayer Ji, Del Bigtree, Sherri Tenpenny and Joe Mercola.

Other themes include the role of various languages, mathematics, art, religions and other symbolic systems to structure subjective reality at the levels of the individual and of culture.

Publishers Weekly described it as "a revolutionary and interactive book—in the sense that it inspires the reader to think out of the ordinary", adding that Eisenstein "will be noted in antiquity as one of the seminal and pioneering storytellers of this new world".

Eisenstein proposes that if we were to feel that the rivers, forests, and creatures of the natural and material world were sacred or at least valuable in their own right, then our response might be more wholesome and ultimately effective.

[36] In this essay, he argued that the nascent global pandemic presented an opportunity for collective spiritual transformation, if systems of political, medical, and informational control are resisted.

Eisenstein's positions on COVID-19 vaccines and public health measures led his publisher, North Atlantic Books, to part ways with him in 2021.

In 2013, journalist and author Rory Spowers described Eisenstein as a "refreshing new voice", saying that he is young, fresh, well-informed, humble but articulate, with a very spiritual perspective.

"[39] In the essay, which was tweeted out[40] by Jack Dorsey, Eisenstein argued that the nascent global pandemic presented an opportunity for collective spiritual transformation, if systems of political, medical, and informational control are resisted.

As the pandemic wore on, he questioned the rationality of public health measures like social distancing and vaccines, and suggested that conspiracy theories conceal truths that society is unprepared to accept.

[41] In 2021, Eisenstein's publisher, North Atlantic Books publicly disavowed his essay "Mob Morality and the Unvaxxed," in which he expressed his belief that those who chose not to be vaccinated for COVID-19 were being persecuted.