[5][6][7] Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases.

Chemerin is a 14 kDa protein secreted in an inactive form as prochemerin and is activated through cleavage of the C-terminus by inflammatory and coagulation serine proteases.

[8][9] Chemerin was found to stimulate chemotaxis of dendritic cells and macrophages to the site of inflammation.

[8] It was found incubation of 3T3-L1 cells with recombinant human chemerin protein facilitated insulin-stimulated glucose uptake.

[15] This suggests chemerin plays a role in insulin sensitivity and may be a potential therapeutic target for treating type II diabetes.