The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids.

NK cells release XCL1 along with IFN-γ and some other chemokines upon encountering certain bacteria such as Listeria or MCMV.

[8] Naive CD8+ T cells are prepared when tumors form by cross-presentation via XCR1+ DCs and as a result will require a lower threshold to respond to antigen.

In order to make a powerful secondary infection response, cytokine and chemokine signaling between XCR1+ DCs and NK cells must occur.

[9] This article incorporates text from the United States National Library of Medicine, which is in the public domain.