After graduating from Princeton University in 1914 and Harvard Medical School in 1920, Gamble began his residency at Massachusetts General Hospital.
He sought a simpler method of contraception, one that did not require a costly doctor's visit as fitting a diaphragm did, and that was inexpensive and immediately available.
This influenced five nearby states—South Carolina, Alabama, Florida, Mississippi, and Virginia—to incorporate birth control into their public health programs.
In 1938, Gamble left Philadelphia and the University of Pennsylvania and moved near Boston, Massachusetts and funded eight field workers who at new community-supported birth control clinics in Montana, Tennessee, the East Coast, and the Midwest.
Koya's Three Village study began fieldwork in November 1950 and by May 1951 showed that 92 percent of the Japanese population wanted contraception.
The resulting India-Harvard-Ludhiana or Khanna study examined the use of contraceptives by Indians in that region and continued for 17 years, generating some three dozen articles, a book, and a monograph.
Rama Rau, Wright, and IPPF said that women of whatever color deserved the best that Western medicine could offer—in this case birth control provided by a fitted diaphragm after an exam by a gynecologist.
Gamble, the Benefactor of the Family Planning Movement in Japan.” Gamble worked closely with and financially supported Dickinson's National Committee on Maternal Health until Dickinson's death in 1950, and gave both financial support and time to Margaret Sanger's Clinical Birth Control Research Bureau.
After the IPPF Japan conference, Gamble, accompanied by his oldest son, Richard, visited doctors who had agreed to test the simple methods.
On that first Asia trip, Clarence and Richard promoted birth control in 13 countries, including Singapore, Hong Kong, and Burma, and assisted local leaders in forming family planning associations in Pakistan, Bangladesh, Sri Lanka, Thailand, and Japan.
[3] The league supported programs of forced sterilization of both men and women, mostly poor, of assumed low IQ, and predominantly African-American, without their consent, with the goal of reducing the state's welfare burden and improving the gene pool.
[4] In addition to paying the salaries of visiting nurses and health workers to staff the clinics and office workers to manage offices, Gamble paid for and distributed print materials: posters in native languages, comic-book-style pamphlets, flyers, reprints of scientific articles, booklets and books, and contraception manuals.
In 1957, at the suggestion of his attorney son-in-law, Lionel Epstein, husband of his oldest child, Sally, his philanthropic activity was incorporated into the new Pathfinder Fund, and Gamble was elected president by the board of directors on February 27, 1957.
Roots; consultation fee for Dr. Luigi DeMarchi, (who, with his wife Maria Luisa DeMarchi, were crusaders for the legalization of birth control in Roman Catholic Italy); salary for a nurse in Hong Kong, who worked in an area of "hillside shacks beyond the ends of roads," occupied by refugees; and in August, supplementary payments of approximately $5 per month were allowed for nurses in Taiwan because the nurses must live in the village "where they were exposed to snakes, barking dogs, and sleeping behind doors with no locks."
Though Gamble supported trials of the pill, its drawbacks included its daily dose requirement and relatively high cost.
In Korea, where as many as 2,000 babies were abandoned yearly in the Seoul streets, the government welcomed this new method of practical birth control.
The Population Council wanted complete control of IUD trials and distribution, but Gamble opened his own manufacturing plant in Hong Kong.
Despite sharp disagreements, Gamble encouraged the clinics and family planning associations that he funded and his fieldworkers opened to become members of PPFA or IPPF, which most did.