[2] At the end of the 19th century, the fear of drug abuse made coca-based drinks less popular.

This led to the prohibition of cocaine in the United States in 1914 via the Harrison Narcotics Tax Act, and the removal of cocaine from coca wine, though coca leaf remained.

[2] Coca wine itself became illegal in the United States when its other main drug, alcohol, was banned just a few years later with the Eighteenth Amendment in 1920.

In 1886, when Georgia introduced Prohibition, Pemberton had to replace the wine in his recipe with non-alcoholic syrup.

[2] The combination of cocaine and alcohol leads to the formation of cocaethylene in the body.