[2] The county and its seat are named after US Vice President (1869-1873) Schuyler Colfax.

[3] In the Nebraska license plate system, Colfax County is represented by the prefix 43 (it had the 43rd largest number of vehicles registered in the county when the license plate system was established in 1922).

The new county was named for Schuyler Colfax, then the vice-president of the United States.

The site of Shell Creek Station on the Union Pacific Railroad was chosen as the county seat, and renamed Schuyler also after Colfax.

[9] As of the 2000 United States census,[18] there were 10,441 people, 3,682 households, and 2,592 families in the county.

The 2020 United States census said that the county was 47.4% non-Hispanic white, 3.5% black African-American, .5% Asian and 47.2% Hispanic.