Coumaroyl-coenzyme A is the thioester of coenzyme-A and coumaric acid.

Coumaroyl-coenzyme A is a central intermediate in the biosynthesis of myriad natural products found in plants.

These products include lignols (precursors to lignin and lignocellulose), flavonoids, isoflavonoids, coumarins, aurones, stilbenes, catechin, and other phenylpropanoids.

[1] It is generated in nature from phenylalanine, which is converted by PAL to trans-cinnamate.

Coumarate is condensed with coenzyme-A in the presence of 4-coumarate-CoA ligase: This article about an aromatic compound is a stub.