Dernice is a comune (municipality) in the Province of Alessandria in the Italian region Piedmont, located about 110 kilometres (68 mi) southeast of Turin and about 40 kilometres (25 mi) southeast of Alessandria.

It is located across the ancient Salt road, a former commercial road between Genoa and the Padan Plain.

It is the seat of production of the Montebore cheese, in the eponymous frazione.

Dernice borders the following municipalities: Borghetto di Borbera, Brignano-Frascata, Cantalupo Ligure, Garbagna, Montacuto, and San Sebastiano Curone.

This article on a location in the Province of Alessandria is a stub.