Dimetindene, also sold under the brand name Fenistil, is an antihistamine/anticholinergic.

[2] Dimetindene is an atypical first generation H1 antagonist as it only minimally[3] passes across the blood–brain barrier.

[6] It is used topically to treat skin irritations, such as insect bites.

Dimetindene is also administered orally to treat allergies, such as hay fever.

It is commonly formulated as its maleic acid salt, dimethindene maleate.