The Greek National Road 48 (Naupactus - Arachova - Livadeia) passes north of the town.

One of the most important monuments of Byzantine architecture and a UNESCO World Heritage Site, the monastery of Hosios Loukas is situated close to Distomo.

During the ancient Greek times there was a settlement called Amvryssos (Amvrossos) part of which is buried under Distomo.

On 10 June 1944, Distomo was the site of a massacre of civilians[4] by the Germans, which constituted a war crime.

The judges awarded the plaintiffs the Villa Vigoni in Menaggio, Italy, a German government-sponsored nonprofit foundation.