It connects the Greek National Road 5 at Antirrio with the town Livadeia, passing through Naupactus and Delphi.

The section between Antirrio and Itea is part of European route E65.

The GR-48 passes through the regional units Aetolia-Acarnania, Phocis and Boeotia.

The western end of the GR-48 is at the north side of the Rio-Antirrio bridge, in Antirrio.

It runs east along the north shore of the Gulf of Corinth, and bypasses the port town Nafpaktos.