Doc Frankenstein is an American comic book series created by Geof Darrow and Steve Skroce, written by the Wachowskis (Lilly and Lana, better known for their work on The Matrix series), drawn by Skroce, and published by Burlyman Entertainment.

The comic tells the story of Frankenstein's monster, who survived the events of Mary Shelley's 1818 novel and adopted his creator's name as his own (and earned doctoral degrees).

Doc Frankenstein has since been involved in world history (flashbacks show him as a gunslinger in the Wild West, a soldier in World War II, a supporter of the teaching of evolution in 1925's Scopes Trial, and a supporter of Roe v. Wade in 1972).

However, the extremely liberal viewpoints he espouses have made him a target of fundamentalists, who have sought to kill him over the years without success.

In November 2019, an oversized deluxe hardcover edition was released that collected the first six issues and added 64 pages that completed the story.