1KL9, 1Q8K196513665ENSG00000134001ENSMUSG00000021116P05198Q6ZWX6NM_004094NM_026114NP_004085NP_080390Eukaryotic translation initiation factor 2 subunit 1 (eIF2α) is a protein that in humans is encoded by the EIF2S1 gene.

[6] Phosphorylation of eIF2α by EIF-2 kinases plays a key role in regulating the integrated stress response.

[7] After reperfusion following brain ischemia, there is inhibition of neuron protein synthesis due to phosphorylation of eIF2α.

Hence proper functioning of eIF2α appears essential for preventing diet-induced type II diabetes.

[10] Salubrinal also blocks eIF2α dephosphorylation by a herpes simplex virus protein and inhibits viral replication.