After she started her modeling career in mid 80's as a commercial model for different television spots, magazines video clips and promotions she pursued a career as actress and co-hostess in different popular tv shows as Cocktail and Mega Banca.
In 2010, Forbes ranked Menegaki as the second-most powerful and influential celebrity in Greece and top-ranked female.
A year later, she and Giorgos Polichroniou hosted the highly successful game show "MEGA Banca."
In 1994, she started in the successful ANT1 comedy TV show "Pater Imon" portraying a radio producer.
She continued hosting the show for 10 years with great success and soon the media named her "Queen of the morning zone."
Despite low ratings in the first season, it soon became a great success, especially in the commercial target group 15–44 years of age.
In 1993, she appeared in an advertisement for the "Famozo" window cleaner, while in 1998, she promoted the Prinos slimming center.
At the age of 20, Menegaki married Greek shop owner Stavros Garderis but they divorced one year later.