[1] He was selected to the all-state first-team as an athlete by The Louisiana Sports Writers Association as a senior.

McGuire attended and played college football for the Louisiana Ragin' Cajuns from 2013–2016.

He started the season off strong with 129 rushing yards and a touchdown against Southern in the 45–6 victory.

In the second game of the season against Northwestern State, he had 14 carries for 165 yards and five rushing touchdowns in the 44–17 victory.

[22] On November 19, against the Georgia Bulldogs, he had 129 rushing yards in the 35–21 loss at Sanford Stadium.

[23] In his final collegiate game, he had 99 rushing yards in the 28–21 loss to Southern Miss in the 2016 New Orleans Bowl.

[29] In Week 2, in the 45–20 loss to the Oakland Raiders, McGuire had six rushes for 29 yards for his debut in the Jets backfield.

[30] On October 1, 2017, during Week 4 against the Jacksonville Jaguars, McGuire rushed for 93 yards, including one for a 69-yard touchdown, as the Jets won 23–20 in overtime.

[36] On September 2, 2019, McGuire was signed to the practice squad of the Cleveland Browns.

[40] On November 25, 2019, McGuire was signed to the Kansas City Chiefs practice squad.

[41] McGuire won Super Bowl LIV with the Chiefs after they defeated the San Francisco 49ers 31–20.

[43] After being released from the Chiefs, the Dallas Cowboys signed McGuire to their practice squad on September 9, 2020.

[48] On December 22, 2020, McGuire signed with the practice squad of the Kansas City Chiefs.