He played college football for the Central Michigan Chippewas, and was selected first overall by the Kansas City Chiefs in the 2013 NFL draft.

[1] He attended Stoney Creek High School, where he was an All-State honorable mention lineman for the football team.

[3] Fisher played at Central Michigan University from 2009 to 2012 where he was recognized as a first-team All-American by Pro Football Weekly, a second-team selection by Sports Illustrated, and received third-team honors from the Associated Press.

[11] Fisher is one of two Central Michigan players to be selected in the first round of an NFL Draft; the other is Joe Staley.

According to Pro Football Focus, his run-blocking grade of −6.5 ranked 55th out of 76 NFL tackles who played at least 25 percent of their team's snaps.

In March 2014, head coach Andy Reid announced that he was moving Fisher to the left tackle position for the upcoming 2014 season, following the loss of Branden Albert in free agency.

[22] He joined Clark Hunt and Andy Reid in accepting the Vince Lombardi Trophy on behalf of the team.

[23] In the Week 3 game of the Chiefs' 2020 season against the Baltimore Ravens, Fisher lined up as an eligible receiver and caught a two-yard pass for a touchdown, the first of his career.

[27] On January 24, 2021, against the Buffalo Bills in the AFC Championship Game, Fisher suffered a torn Achilles, forcing him to miss Super Bowl LV.