It should not be confused with a similarly named stream that runs through Fourmile Canyon west of Boulder, which was the site of a major wildfire in 2010.

It runs eastward through the foothills of the Front Range in Boulder County, Colorado, south of Left Hand Canyon and north of Sunshine Canyon.

The creek exits the mountains to the plains near Lee Hill Road in northern Boulder, then flows east an additional 5 mi (8.0 km) through the plains to its confluence with Boulder Creek near Valmont.

This stream is home to Boulder Open Space land, a trailhead, and the Anne U.

[2] Although Fourmile Canyon Creek is a seasonal intermittent stream in the plains, it is also the target of flash flood prevention efforts.