The Frankfurt–Warsaw railway, which runs generally to the east, takes a big curve in a southerly direction in Frankfurt to cross the deep Oder valley.

The vast and now largely unused property north of the passenger station on the line towards Eberswalde was formerly used for local freight transport operations.

In addition to the direct route via Fürstenwalde and Jacobsdorf, which was eventually built, there were also proposals for a line to the southeast via Müllrose that would have run into the Oder valley and reached Frankfurt from the south.

[4] The Niederschlesisch-Märkische-Eisenbahngesellschaft ("Lower Silesian-Markish Railway Company”, with “Markish” referring to the March of Brandenburg—Mark Brandenburg) was founded in 1842.

[6] On the site of the old station, the Niederschlesisch-Märkische railway company, which was headed by August Wöhler, built its central workshop to replace earlier facilities that were in Berlin and Breslau.

The section from Frankfurt via Küstrin (now Kostrzyn nad Odrą in Poland) to Kreuz (Krzyż Wielkopolski) was opened on 12 October 1857.

The direct connection from Berlin via Strausberg to Küstrin opened in 1866 and the traffic from the Eastern Railway bypassed Frankfurt.

The line between Leipzig and Poznań was built via Guben, Frankfurt only received a branch towards Posen via Bentschen (now Zbąszyń).

In the construction of this line, difficulties were created by the large difference in height between the Oder valley and rolling hills to the west of Frankfurt.

Even before the First World War construction work began on a large marshalling yard north of the station on the Eberswalde line, which became operational in 1917.

For eleven weeks, the city was the scene of heavy fighting between the German Wehrmacht and the Red Army.

The section of the line to Küstrin between Frankfurt and Wüste Kunersdorf junction near Lebus was dismantled as war reparations to the Soviet Union and never rebuilt.

For several decades until the mid-1920s, trains ran to Warsaw via Toruń as there was a continuous connection over the then recently completed Warsaw–Poznań railway.

Between the world wars, some express trains ran between Stettin (Szczecin) and Breslau via Küstrin and Frankfurt.

From 1926 until the Second World War, frequent suburban service ran to the extensive facilities of the marshalling yard.

The long-distance services from Berlin to Poland and the Soviet Union went through Frankfurt, the new Polish border station of Kunowice and the junction at Rzepin.

Only a small proportion of these trains were available for domestic traffic in East Germany (the GDR) between Berlin and Frankfurt.

During the existence of the GDR, some express trains ran in the north–south direction from Angermünde and Frankfurt and continued towards Dresden.

Some semi-fast passenger services went directly to Berlin-Karlshorst, some continuing to Berlin Ostbahnhof, and stopped on the route only at Fürstenwalde or at a few other stations.

One of these train pairs ran daily from Frankfurt via Eberswalde, Fürstenberg (Havel), Neustrelitz and Güstrow to Schwerin.

Since 1998, the RE services have operated at approximately half-hour intervals between Frankfurt and Berlin, some continuing to Potsdam, Brandenburg and Magdeburg.

At the end of the platform on the east side of the station there was a shed for wagons, locomotives and freight and a mail handling facility.

The mail handling facility became a residence for rail officials and the passenger station building was used for administrative purposes.

[14] The through line running from Berlin to Breslau (Wrocław) was built on a curve to the right towards the south in the station area.

The form and details of the facades of the crenelated, neo-renaissance structure with arched windows and cornices with coupled small arched windows in the mezzanine marks the common origin of these buildings,[15] only the towers at the ends of the buildings were not also built here.

The marshalling yards of the Eastern Railway were built to the north of the so-called Ostbahnhof section of the station.

The tram stops are located about 100 metres north of the entrance building at the underpass to Beresinchen (the Beresinchentunnel).

Between the bus station and the tram stop is the newly reconstructed "City Residence Hotel Frankfurt Oder".

It is located on a steep slope above the Oder valley and was built by the Ostmark company with apartments for railway workers as part of the transfer of the Deutsche Reichsbahn divisional administration to Frankfurt.

Between the apartments designed by Beringer is a monument made by the sculptor Furstenberg for 1535 railwaymen who died in the First World War.