Along the Coffee–Irwin county line stretch, it intersects SR 90 (Lax Highway).

Then, it continues to the southeast, until it meets is eastern terminus, an intersection with US 82/SR 520 (Albany Highway) northwest of Waycross.

Just before a local farm and ranch supply store, the routes curve towards the east before encountering the former Central of Georgia Railway right-of-way next to Georgia State Route 135, which joins the overlap.

All routes run along the north side of the Douglas Municipal Airport.

SR 206 ends at US 221/441/SR 31, and US 221 joins the route, Just before reaching Brantley Boulevard the road starts to curve northeast.