It travels completely within Glynn County, and is in the Brunswick metropolitan area.

SR 303 begins at an intersection with US 17/SR 25/SR 520 southwest of Brunswick, which is also the eastern terminus of US 82.

The route travels northeast across the South Brunswick and Turtle rivers, then arcs to the east.

It then makes a curve to the southeast, meeting an intersection with SR 25 Spur.

The highway continues southeast, meeting its northern terminus, a second intersection with US 17/SR 25 in Country Club Estates.