State Route 358 (SR 358) is a 6.4-mile-long (10.3 km) west–east state highway located entirely in the southeastern part of Twiggs County in the central part of the U.S. state of Georgia.

The route travels to the east-northeast along Homer Chance Highway to an interchange with Interstate 16 (I-16) just east of its midpoint.

It continues to the east-northeast and meets its eastern terminus, an intersection with US 80/SR 19 west of Danville.

[1] SR 358 is not part of the National Highway System, a system of roadways important to the nation's economy, defense, and mobility.

[4] SR 358 was built, and paved, along its current alignment between 1963 and 1966.