Grassano is a town and comune in the province of Matera, in the southern Italian region of Basilicata.

It is located between the Bradano and Basento rivers at an elevation ranging from about 150 to 576 metres (492 to 1,890 ft) above sea level.

In Grassano, Levi painted about 70 pictures and started discovering southern Italy's problems.

He described his experiences in Grassano in his most famous book, Christ Stopped at Eboli, which was published after the Second World War in 1945.

Anna Briganti, the grandmother of former New York Mayor Bill de Blasio, originated in Grassano.