Miglionico (Lucano: Megghiuòneche) is a town and comune in the province of Matera, in Basilicata, southern Italy.

[3] Despite the legend assigning its foundation to the famous Greek wrestler Milo of Croton (whence the name), Miglionico was most likely founded by the Oenotrians, a local Italic tribe.

After the Greek colonization, it was held by the Lucani, followed by the Samnites until 458 BC, when it was conquered by the Romans.

In the Middle Ages the story of Miglionico was strongly connected to that of its large castle, which was held by the Hauteville Normans and then by the Sanseverino.

After the latter where slaughtered by order of Frederick II (1245), Miglionico was assigned to his son Manfred.