Homer1 is expressed widely in the central nervous system as well as peripheral tissue including heart, kidney, ovary, testis, and skeletal muscle.

[10] Also, through crosslinking another multimeric protein Shank, it is proposed to comprise a core of the postsynaptic density.

In this way, the short form of Homer uncouples mGluR signaling and also shrinks dendritic spine structure.

[6][14] Therefore, the short form of Homer is considered to be a part of a mechanism of homeostatic plasticity that dampens the neuronal responsiveness when input activity is too high.

Homer1a switches mGluR5 signaling to increase AMPA receptor activity for the rapid antidepressant actions of sleep deprivation.