[2] Inositol triphosphate receptor represents a dominant second messenger leading to the release of Ca2+ from intracellular store sites.

There is strong evidence suggesting that the InsP3R plays an important role in the conversion of external stimuli to intracellular Ca2+ signals characterized by complex patterns relative to both space and time, such as Ca2+ waves and oscillations.

[3] The InsP3 receptor was first purified from rat cerebellum by neuroscientists Surachai Supattapone and Solomon Snyder at Johns Hopkins University School of Medicine.

The initial sequencing was reported as an unknown protein enriched in the cerebellum called P400.

Several X-ray crystallographic [7][8][9] and electron cryomicroscopic (cryo-EM) [10][11][12][13][14][15][16] structures of IP3Rs from mouse, rat, and human have defined the overall architecture of the channel.