[7] RYR1 is associated with the dihydropyridine receptor (L-type calcium channels) within the sarcolemma of the T-tubule, which opens in response to depolarization, and thus effectively means that the RYR1 channel opens in response to depolarization of the cell.

This coincides with the observation that without RYR1 present, muscle cells appear in smaller groups, are underdeveloped, and lack organization.

RYR1 is mechanically linked to neuromuscular junctions for the calcium release-calcium induced biological process.

Although their direct role is still unknown, RYR1 is required for proper distribution of acetylcholine receptor clusters.

[citation needed] RYR1 has been shown to interact with: This article incorporates text from the United States National Library of Medicine, which is in the public domain.