He obtained a degree in physics and worked at the Kaiser Wilhelm Institut, Berlin Dahlem, from 1929 until 1932 with Prof. Otto Hahn and Prof. Lise Meitner.
Disgruntled by lack of recognition, Hupfeld left the Kaiser Wilhelm Institut in 1932 (now known as the Max Planck Society) in Berlin and went, because of Germany's bad economic situation at that time, to help in the construction of buildings using a sustainable earthen technology known as the "Dunne loam loaf" technique,[2] pioneered in Europe by Pastor Gustav von Bodelschwingh, Ruhrgebiet, Germany.
From there he went to the recently founded "Freiwilliger Arbeitsdienst" (FAD) also created by v. Bodelschwingh, but was very suddenly incorporated by the Nazi regime into the "Reichsarbeitsdienst" (RAD) at Schloss Simmenau, High Silesia and Oppeln/OS (after World War II, known as Opole, Poland).
From there he left to serve as a Reserve Officer until his death at the age of 36 during World War II in the Russian Caucasus.
According to letters sent by the German army to his widow, he was killed on November 11, 1942, in Nisch Ssaniba, North Ossetia, Caucasus.