In the United States, the Environmental Protection Agency has limited the sale of heptachlor products to the specific application of fire ant control in underground transformers.
The resulting adduct is chlorinated followed by treatment with hydrogen chloride in nitromethane in the presence of aluminum trichloride or with iodine monochloride.
[4] Compared to chlordane, it is about 3–5 times more active as an insecticide, but more inert chemically, being resistant to water and caustic alkalies.
When heptachlor epoxide was incubated with microsomal preparations form liver of pigs and from houseflies, the products found were diol and 1-hydroxy-2,3-epoxychlordene.
Like other POPs, heptachlor is lipophilic and poorly soluble in water (0.056 mg/L at 25 °C), thus it tends to accumulate in the body fat of humans and animals.
A product of hydrogenation of heptachlor, β-dihydroheptachlor, has high insecticidal activity and low mammalian toxicity, rat oral LD50>5,000mg/kg.
Exposure to higher doses of heptachlor in newborn animals leads to decreased body weight and death.
The Occupational Safety and Health Administration has limit of 0.5 mg/m3 (cubic meter of workplace air) for 8-hour shifts and 40-hour work weeks.