Himbacine is an alkaloid isolated from the bark of Australian magnolias.

Himbacine has been synthesized using a Diels-Alder reaction as a key step.

[1] Himbacine's activity as a muscarinic receptor antagonist, with specificity for the muscarinic acetylcholine receptor M2, made it a promising starting point in Alzheimer's disease research.

[2][3] The development of a muscarinic antagonist based on himbacine failed but an analog, vorapaxar, has been approved by the FDA as a thrombin receptor antagonist.

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