Hypobetalipoproteinemia is a disorder consisting of low levels of LDL cholesterol or apolipoprotein B,[1] below the 5th percentile.

[2] The patient can have hypobetalipoproteinemia and simultaneously have high levels of HDL cholesterol.

In 1997 a study showed that Japanese Centenarians had tenfold increase of hypobetalipoproteinemia compared with controls.

[3] Another form is associated with microsomal triglyceride transfer protein which causes abetalipoproteinemia.

[citation needed] Early high doses of vitamin E in infants and children has shown to be effective.