[2][3][4] Its main mode of action is via blocking of neuronal sodium channels, belonging to IRAC group 22A.

This pesticide should be used with caution since some insects such as the oriental tobacco budworm (Helicoverpa assulta) become resistant when exposed.

[12] While toxicity to humans has not been formally studied, there is a reported case of a person consuming indoxacarb in a suicide attempt.

[13] Methemoglobinemia (also known as blue baby syndrome) is a condition which ultimately decreases the effectiveness of red blood cells to exchange oxygen with organs.

Methemoglobinemia can be fatal if left untreated, however when the cause is exposure to a chemical agent (not genetic) a variety of treatments are available and effective.