KY 1143 starts at an interchange with U.S. Route 460 (US 460) and US 460 Bypass near Great Crossing.

Shortly after, it intersects Betsy Way to provide access to Great Crossing High School.

It then runs through a rural area until its terminus at KY 32.

[1] It is primarily used by Scott County Schools, and Toyota.

The entire route is in Georgetown, Scott County.