Keratin 7

4XIF3855110310ENSG00000135480ENSMUSG00000023039P08729Q9DCV7NM_005556NM_033073NP_005547NP_149064Keratin, type II cytoskeletal 7 also known as cytokeratin-7 (CK-7) or keratin-7 (K7) or sarcolectin (SCL) is a protein that in humans is encoded by the KRT7 gene.

It is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels.

The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues.

This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels.

Epithelial cells of the lung and breast both contain keratin-7, but some other glandular epithelia, such as those of the colon and prostate, do not.

Immunohistochemistry for CK7 of a metastatic undifferentiated carcinoma to a lymph node.