Lectins are structurally diverse proteins that bind to specific carbohydrates.

[1] Although proteins containing this domain were originally identified as a family of animal lectins, there are also yeast representatives.

[1] ERGIC-53 is a 53kDa protein, localised to the intermediate region between the endoplasmic reticulum and the Golgi apparatus (ER-Golgi-Intermediate Compartment, ERGIC).

[2] Its dysfunction has been associated with combined factors V and VIII deficiency, suggesting an important and substrate-specific role for ERGIC-53 in the glycoprotein-secreting pathway.

[2][3] The L-like lectin domain has an overall globular shape composed of a beta-sandwich of two major twisted antiparallel beta-sheets.