3P2T1100614727n/aENSMUSG00000112023Q8NHJ6Q61450NM_001278430NM_006847NM_001394933NM_001394934NM_001394935NM_001394936NM_001394937NM_001394938NM_001394939NM_001291892NM_001291893NM_008147NP_001265355NP_001265356NP_001265357NP_001265358NP_001265359NP_001278821NP_001278822NP_032173Leukocyte immunoglobulin-like receptor subfamily B member 4 is a protein that in humans is encoded by the LILRB4 gene.

The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs).

The receptor is expressed on monocytic cells and transduces a negative signal that inhibits stimulation of an immune response.

It has been shown to express on tumor-associated macrophages and negatively regulate immune response in tumor.

[10] This article incorporates text from the United States National Library of Medicine, which is in the public domain.