The lamin family of proteins make up the matrix and are highly conserved in evolution.

During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated.

Lamin proteins are thought to be involved in nuclear stability, chromatin structure, and gene expression.

[8][9] When double-strand breaks are induced in DNA by ionizing radiation, lamin B1 promotes repair of the breaks, as well as cell survival, by maintaining the level of the RAD51 protein that is employed in homologous recombinational repair.

[10] Mutations affecting the LMNB1 gene cause autosomal dominant adult-onset demyelinating leukodystrophy.