The La Crosse River is a 61.3-mile-long (98.7 km)[3] tributary of the Mississippi River in southwestern Wisconsin in the United States.

The La Crosse River rises in northern Monroe County and flows generally west-southwestwardly into La Crosse County, through the Fort McCoy military installation and past Sparta, Rockland, Bangor and West Salem.

It flows into the Mississippi River at the city of La Crosse.

[4] In Monroe County, it collects the short Little La Crosse River, which flows for its entire course in Monroe County.

This article related to a river in Wisconsin is a stub.