[3][4] Its flagship hospital, Lehigh Valley Hospital–Cedar Crest, located at 1200 South Cedar Crest Boulevard in Allentown, is the state's third-largest hospital, Pennsylvania's first Level One Trauma Center, and one of two Level One trauma centers in the Lehigh Valley, the state's third-most populous metropolitan region with 861,889 residents as of 2020.

St. Luke’s University Health Network’s Bethlehem Hospital, located in Fountain Hill, is the only other Level One trauma center in the Lehigh Valley.

[5] The Lehigh Valley Health Network Cancer Center, based on its Cedar Crest Boulevard campus, is the fourth-largest in Pennsylvania, treating over 2,400 new patients annually.

The not-for-profit supports over 11,000 free flu shots, which are offered at Dorney Park & Wildwater Kingdom in South Whitehall Township and Coca-Cola Park in East Allentown, and a dental van that provides free care to more than 1,000 children annually and covers the differential between health care costs and how much Medicaid and Medicare reimburse.

The larger entity will have revenues over $13 Billion and over 2,000 hospital beds easily surpassing Penn Medicine to become the second largest health network in Pennsylvania behind Pittsburg based UPMC.