LXR-β is encoded by the NR1H2 gene (nuclear receptor subfamily 1, group H, member 2).

Like other receptors in the family, LXRs heterodimerize with retinoid X receptor and bind to specific response elements (LXREs) characterized by direct repeats separated by 4 nucleotides.

Two genes, alpha (LXRA) and beta, are known to encode LXR proteins.

[5][6] Crystal structure of human liver X receptor β(LXRβ) forming heterodimer with its partner retinoid X receptor α(RXRα) on its cognate element, an AGGTCA direct repeat spaced by 4 nt shows an extended X-shaped arrangement, with DNA- and ligand-binding domains crossed.

[9] This article incorporates text from the United States National Library of Medicine, which is in the public domain.