Written by Shonda Rhimes and directed by Mark Tinker, the episode originally aired on May 15, 2006, on American Broadcasting Company (ABC), as part of a two-hour season finale event alongside "Deterioration of the Fight or Flight Response".

The show follows a group of young doctors in training, and in this episode, Izzie Stevens (Katherine Heigl) and her fellow interns are tasked with planning a prom for Richard Webber (James Pickens Jr.) niece, Camille Travis (Tessa Thompson).

Other major storylines include Preston Burke (Isaiah Washington) recovering from his gunshot wound and the emotional fallout following Denny Duquette's (Jeffrey Dean Morgan) death after his seemingly successful heart transplant.

Several guest stars reprised their roles, including Morgan, Thompson, Brooke Smith, Sarah Utterback, Loretta Devine, and Chris O'Donnell, while Hallee Hirsh and Tiffany Hines made their first and only appearances.

[1][2][3][4] Derek Shepherd (Patrick Dempsey) and Richard Webber (James Pickens Jr.) complete Preston Burke's (Isaiah Washington) surgery to repair a pseudo-aneurysm in his subclavian artery, caused by a gunshot wound, which had jeopardized the functioning of his arm.

Meanwhile, the interns are ordered by Webber to organize a prom for his dying niece, Camille Travis (Tessa Thompson), until the one responsible for cutting Denny’s left ventricular assist device (LVAD) wire confesses.

In a pivotal moment, Izzie confesses to Webber that she was the one who cut Denny's LVAD wire, and overwhelmed by guilt, she declares that she can no longer be a surgeon, quitting the program.

[6] The episode featured recurring performances by Ramirez (Torres), Jeffrey Dean Morgan (Denny Duquette), Tessa Thompson (Camille Travis), Brooke Smith (Erica Hahn), Sarah Utterback (Olivia Harper), Loretta Devine (Adele Webber) and Chris O'Donnell (Finn Dandrige), while Hallee Hirsh and Tiffany Hines made their first and only appearances as Claire and Natalie, respectively.

[7] The soundtrack for the episode included Pete Droge's "Under the Waves", Dressy Bessy's "Side 2", Amos Lee's "Colors", Masha Qrella's "Destination Vertical", Kate Havnevik's "Grace", and Snow Patrol's "Chasing Cars".

[8] The use of "Chasing Cars" notably increased the American profile of Snow Patrol, with lead singer Gary Lightbody initially hesitant about licensing the song but later acknowledging the positive impact the publicity had on the band.

[5] "Losing My Religion" originally aired on May 15, 2006, in the United States on the American Broadcasting Company (ABC), alongside the episode "Deterioration of the Fight or Flight Response" as part of a two-hour season finale.

However, Keller criticized the lack of realism in the interns' punishments, finding the Meredith Grey (Ellen Pompeo)/Derek Shepherd (Patrick Dempsey) storyline tiresome, and described the cliffhanger as a "lame cliché".

While she appreciated the emotional scene of Doc's death, Ryan was critical of Torres' underdeveloped character, her lack of chemistry with George O'Malley (T. R. Knight), and her prom dress.