MRNA-based disease diagnosis

[1] as molecular diagnostic tools to discover the relationships between patient's DNAs and their specific biological features.

For example, in hepatocellular carcinoma,[3] the tumor tissues excised during the operation are a good resource for mRNA-based test to analysis.

[11] However, for the triple negative breast cancer, none of those biomarkers can be detected leaving it with poor prognosis and high mortality.

Even though there is no obvious symptom, the mRNA-based disease diagnostic technology can serve as screening method for early changes in RNA levels.

[23] High serum metadherin mRNA expression was observed in colorectal cancer and associated with poorly differentiated histological grades[24]