[8][9][10] In the presence of cargo adapters and calcium, unconventional myosin Va is present in an elongated and active state.

The actin-binding head (N-Terminal) is an ATP-dependent motor domain that transmits changes from the active site to the light chain lever arm.

The C-terminal globular domain (GB) decides the Myosin class and moderate the cargo transport.

Also, the GB interacts with other cargo specific proteins.

Myosin Va is highly expressed in neurons and melanocytes.