[1] It is an affiliated teaching hospital of the Faculty of Medicine, Prince of Songkla University.

[2][3] The construction of Nakhon Si Thammarat Hospital started in 1952 on a 37 rai piece of land owned by Prince Yugala Dighambara, Prince of Lopburi that was location of the Pho Yai Rot Palace, his place of residence when he was viceroy of the South.

In 1978, under the prime ministership of Kriangsak Chamanan, approved for the rapid construction of a 1000-bed hospital in Nakhon Si Thammarat and the hospital was renamed Maharaj Nakhon Si Thammarat Hospital in honour of King Bhumibol Adulyadej and in commemoration of the Rattanakosin Bicentennial.

This began in 1980 and finished completely in 1983, with a total investment of 360 million Baht.

The new hospital was opened on 12 September 1982 by King Vajiralongkorn (then Crown Prince).