It is classified under the Ministry of Public Health as a general hospital.

Initially, when King Mongkut constructed the Phra Nakhon Khiri palace in 1861, he allowed a small missionary team to set up within the town below the palace.

It still operates as The Red Cross Health Station 8 today.

It was renamed Phrachomklao Hospital on 2 March 1989 in commemoration of King Mongkut.

It is currently a general hospital with a capacity of 447 inpatient beds as of 2022.