It has a CPIRD Medical Education Center which trains doctors for the Faculty of Medicine of Thammasat University.

The hospital was officially opened on 14 January 1954.

In 1972-1976, the hospital was designated to be a regional hospital in Central Thailand, under the Third National Economic and Development Plan and was expanded to 600 beds.

In 1993, the hospital made an agreement with the Faculty of Medicine, Thammasat University to train medical students at clinical years 4 and 5 in the fields of internal medicine, surgery, obstetrics and gynaecology, paediatrics and anaesthesiology.

Teaching of students under the Collaborative Project to Increase Production of Rural Doctors (CPIRD) was started in 1995, when a Medical Education Center was built at Saraburi Hospital.