Samut Sakhon Hospital (Thai: โรงพยาบาลสมุทรสาคร) is the main public hospital of Samut Sakhon Province, Thailand and is classified under the Ministry of Public Health as a regional hospital.

It is an affiliated teaching hospital of the Faculty of Medicine Siriraj Hospital, Mahidol University.

Construction began on 14 October 1958, initiated by San Ekmahachai, the governor of Samut Sakhon Province.

The building was completed and opened on 9 December 1959.

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