[1] Collins attended Center High School in Kansas City, Missouri, where he was an outstanding athlete in both American football and wrestling.

[3] After his junior season, Collins decided to forgo his senior year and enter the 2016 NFL draft.

[9] He suffered a broken right foot during the first week of organized team activities, he was placed on the physically unable to perform list and missed most of the preseason.

Collins began his rookie season as the fourth defensive tackle on the depth chart behind the veterans Tyrone Crawford, Terrell McClain and Cedric Thornton.

[10] Although he made his professional regular season debut in the Cowboys’ season-opening loss to the New York Giants, he did not record a statistic.

The improved play he showed in the second game of the season against the Washington Redskins made the Cowboys decide in the fourth quarter to move Crawford to left defensive end and keep Collins as the full-time one-technique tackle, where he was playing out of position.

On November 9, 2016, Collins made his first career sack on Cleveland Browns quarterback Cody Kessler.

During a Week 13 win over the Minnesota Vikings, Collins made two combined tackle and sacked Sam Bradford for his third of the season.

On December 18, 2016, Collins made one solo tackle, and sacked Tampa Bay Buccaneers quarterback Jameis Winston causing a forced fumble, the first of his career, helping the Cowboys win 26–20.

In the Week 2 against the Denver Broncos, Collins's teammate DeMarcus Lawrence forced a fumble off of quarterback Trevor Siemian.

His first start of the season came in the eighth game against the Tennessee Titans, making a season-best 5 tackles with one for a loss.

On March 14, 2024, Collins was traded to the San Francisco 49ers for first of the 49ers two seventh-round picks (#232-Levi Drake Rodriguez).