In this game, the players (led by Gwen Poole) battle each other using cards representing characters from the Marvel Universe.

The story follows the invasion of the villainous metafictional Dark Gwenpool into the past as she steals the superpowers of the heroes of the Marvel Universe, as her heroic present-day counterpart, the game's protagonist Gwen Poole, a girl from the real world, must help the heroes, including Spider-Man, Iron Man, Thor Odinson, and Star-Lord, track her future self down before she brings all of creation to an end.

For each game, the player selects one of the super heroes to use as their avatar, which are separate from their cards and can bring additional skill actions into play.

For example, while using a deck consisting of Elektra, Doctor Strange and Spider-Man archetypes, the player using Star-Lord as their avatar will still be able to choose between Elektra, Doctor Strange and Spider-Man skills to use, while the benefit of using Star-Lord is to increase his level and eventually unlock additional skills.

Certain restriction still apply and the players can tweak the order of their cards during the Preparation phase in hopes of a more desirable outcome.

After all characters on one side are defeated, the winning side deals damage to the losing avatar equal to their shop level plus the total star level of their surviving characters; if the player's avatar's health reaches zero, they are likewise eliminated from the table.

In the Solo mode, training matches against AI opponents and short story-based missions which award cards and booster packs are also available.

[4] The author of the TCG-dedicated blog Duel Links Forum gave the game a positive review, noting the quality of character models and animations, the game's overall stability and lack of major bugs and the good balance, as neither superhero felt superior to all others, nor did the cash shop guarantee a pay-to-win scenario.